Farmapram (alprazolam) help for acute stress disorder
Many depressed patients had symptoms of somatic anxiety (including somatized depression), which disappeared along with mental anxiety. Probably, in this case we can speak about vegetotropic effect of farmapram, as well as of other benzodiazepines (phenazepam, diazepam). Another explanation is possible: together with anxiety its somato-vegetative “accompaniment” leaves.
In the history of many patients with panic disorder, anxiety-phobic disorders, recurrent depression, episodes of effective use of farmapram (alprazolam) with tianeptine with fairly rapid reduction of symptoms and restoration of social functioning were noted. In organic brain lesions, alprazolam was used as an anti-anxiety and sedative in combination with low doses of sedative antipsychotics (clozapine, olanzapine), nootropics. Duration of therapy – no more than one month, daily doses – up to 0.75 mg. Antipsychotics in these cases were prescribed as behavioral adjusters, and alprazolam “softened” the side effects.
In sluggish schizophrenia, alprazolam was prescribed as part of a polymorphic neurosis-like syndrome, which included anxiety-phobic, panic, obsessive-compulsive and depressive disorders. As a rule, it was used in combination with antidepressants (Rexetine, mirtazapine, amitriptyline), neuroleptics (sulpiride, Sonapax, chlorprotixen, quetiapine), hypnotics (zopiclone, zolpidem), short courses of two to four weeks at a dose of 0.5-0.75 mg daily.
A special group consisted of paranoid schizophrenia patients for whom alprazolam was prescribed in addition to neuroleptics (clozapine, olanzapine, paliperidone, risperidone) as an anti-anxiety agent and potentiating sedative effect. This allowed us to reduce the doses of antipsychotics, which is especially important for outpatient treatment in order to improve social adaptation and quality of life. Courses of therapy of varying duration, from two weeks to several months, depending on the indications, the drug dosage was 1-1.5 mg per day.
Thus, the performed study confirmed that alprazolam has high anxiolytic activity even at low doses with negligible intensity of sedative and hypnotic effects, which allows its use as a daily tranquilizer and anxiolytic in patients with a wide range of anxiety-phobic and panic disorders of various genesis. Alprazolam advantageously differs from other benzodiazepines in the presence of antidepressant action, so it can be used for treatment of not only anxiety, but also depressive disorders. There is good tolerability and high safety of the drug, as well as practical absence of risk of drug addiction when using low doses and strict observance of indications for use. Alprazolam can be prescribed in inpatient and outpatient settings, both in short courses and for long periods, depending on the nature of the psychiatric disorders.